The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) Study
Stroke is a major cause of serious disability among adults in Korea and worldwide, and the incidence of stroke has increased along with the average age of the population. Knowledge about factors to predict long-term functional outcome after stroke are important for setting suitable management plans, enabling discharge planning, and correctly informing prognosis to patients and their families.
The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a 10-years long-term follow-up study using a prospective multi-center design investigating residual disabilities and functional limitations of patients who have suffered from their first-ever stroke. Between August 2012 and May 2015, 7,858 out of 10,636 first-ever stroke patients provided informed consent to participate in this follow-up study from the nine district hospitals in Korea. The KOSCO collect multi-faceted serial face-to-face functional assessment data for ischemic and hemorrhagic stroke patients.
Multifaceted functional assessment
was measured at 7 days after stroke as a baseline, and then repeatedly at 3 ms, 6 ms, 12 ms, 18 ms, 24 ms, 30 ms, 36 ms, and every year thereafter until 10 years after stroke onset. The assessment included the functional independence, cognitive function, motor impairment, swallowing function, language function, mood status, and quality of life. Licenced occupational or physical therapists were participated as assessors after completing designated training program for the face-to-face functional assessment. To keep the quality of assessment and interrater reliability, all assessors underwent repeated training program every 3 months during the course of the study.
This data provides current epidemiologic status of stroke survivors in Korea and will be used to determine clinically meaningful predictive factors for functional outcomes and to crate prediction models of first-time stroke patients.
Restoration of Gait Neural Network Using
ROBOT-NIBS AI Rehabilitation system (RESTORE)
The purpose of this study is to collect and analyze the serial recovery data of lower extremity motor function to establish better rehabilitation strategies for gait function recovery of stroke patients. We measure serial data for a total of 9 times from 1 week to 6 months after the onset of stroke. Measurements include gait analysis (joint angle, moment, muscle activation and ground reaction force), structural and functional brain images (MRI and DTI), neurophysiological assessment, motor and cognitive function assessment, etc.
The final goal of this study is to derive the optimal treatment method to maximize recovery of gait function and restoration of gait-related neural network by establishing the AI-based Personalized CNS-PNS Hybrid Rehabilitation System.